Correlations between gray matter reductions and cognitive deficits in dementia with Lewy Bodies and Parkinson's disease with dementia
Identifieur interne : 002375 ( Main/Exploration ); précédent : 002374; suivant : 002376Correlations between gray matter reductions and cognitive deficits in dementia with Lewy Bodies and Parkinson's disease with dementia
Auteurs : Cristina Sanchez-Castaneda [Espagne] ; Ramon Rene [Espagne] ; Blanca Ramirez-Ruiz [Espagne] ; Jaume Campdelacreu [Espagne] ; Jordi Gascon [Espagne] ; Carles Falcon [Espagne] ; Matilde Calopa [Espagne] ; Serge Jauma [Espagne] ; Montserrat Juncadella [Espagne] ; Carme Junque [Espagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-09-15.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Analysis of Variance, Brain (pathology), Brain Mapping, Cognition Disorders (etiology), Cognition Disorders (pathology), Female, Humans, Lewy Body Disease (complications), Lewy Body Disease (pathology), Lewy body disease, MRI, Magnetic Resonance Imaging (methods), Male, Middle Aged, Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (pathology), Parkinson's disease, Psychiatric Status Rating Scales, Statistics as Topic, Statistics, Nonparametric, dementia, neuropsychology.
- MESH :
- complications : Lewy Body Disease, Parkinson Disease.
- etiology : Cognition Disorders.
- methods : Magnetic Resonance Imaging.
- pathology : Brain, Cognition Disorders, Lewy Body Disease, Parkinson Disease.
- Aged, Aged, 80 and over, Analysis of Variance, Brain Mapping, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Statistics as Topic, Statistics, Nonparametric.
Abstract
There is controversy regarding whether Dementia with Lewy Bodies (DLB) and Parkinson's disease with dementia (PDD) may or not be different manifestations of the same disorder. The purpose of the present study was to investigate possible correlations between brain structure and neuropsychological functions in clinically diagnosed patients with DLB and PDD. The study sample consisted of 12 consecutively referred DLB patients, 16 PDD patients, and 16 healthy control subjects recruited from an outpatient setting, who underwent MRI and neuropsychological assessment. Voxel‐based morphometry results showed that DLB patients had greater gray matter atrophy in the right superior frontal gyrus, the right premotor area and the right inferior frontal lobe compared to PDD. Furthermore, the anterior cingulate and prefrontal volume correlated with performance on the Continuous Performance Test while the right hippocampus and amygdala volume correlated with Visual Memory Test in the DLB group. In conclusion, DLB patients had more fronto‐temporal gray matter atrophy than PDD patients and these reductions correlated with neuropsychological impairment. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22488
Affiliations:
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The purpose of the present study was to investigate possible correlations between brain structure and neuropsychological functions in clinically diagnosed patients with DLB and PDD. The study sample consisted of 12 consecutively referred DLB patients, 16 PDD patients, and 16 healthy control subjects recruited from an outpatient setting, who underwent MRI and neuropsychological assessment. Voxel‐based morphometry results showed that DLB patients had greater gray matter atrophy in the right superior frontal gyrus, the right premotor area and the right inferior frontal lobe compared to PDD. Furthermore, the anterior cingulate and prefrontal volume correlated with performance on the Continuous Performance Test while the right hippocampus and amygdala volume correlated with Visual Memory Test in the DLB group. In conclusion, DLB patients had more fronto‐temporal gray matter atrophy than PDD patients and these reductions correlated with neuropsychological impairment. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Espagne</li></country><region><li>Catalogne</li></region><settlement><li>Barcelone</li></settlement></list><tree><country name="Espagne"><region name="Catalogne"><name sortKey="Sanchez Astaneda, Cristina" sort="Sanchez Astaneda, Cristina" uniqKey="Sanchez Astaneda C" first="Cristina" last="Sanchez-Castaneda">Cristina Sanchez-Castaneda</name></region><name sortKey="Calopa, Matilde" sort="Calopa, Matilde" uniqKey="Calopa M" first="Matilde" last="Calopa">Matilde Calopa</name><name sortKey="Campdelacreu, Jaume" sort="Campdelacreu, Jaume" uniqKey="Campdelacreu J" first="Jaume" last="Campdelacreu">Jaume Campdelacreu</name><name sortKey="Falcon, Carles" sort="Falcon, Carles" uniqKey="Falcon C" first="Carles" last="Falcon">Carles Falcon</name><name sortKey="Gascon, Jordi" sort="Gascon, Jordi" uniqKey="Gascon J" first="Jordi" last="Gascon">Jordi Gascon</name><name sortKey="Jauma, Serge" sort="Jauma, Serge" uniqKey="Jauma S" first="Serge" last="Jauma">Serge Jauma</name><name sortKey="Juncadella, Montserrat" sort="Juncadella, Montserrat" uniqKey="Juncadella M" first="Montserrat" last="Juncadella">Montserrat Juncadella</name><name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junque">Carme Junque</name><name sortKey="Ramirez Uiz, Blanca" sort="Ramirez Uiz, Blanca" uniqKey="Ramirez Uiz B" first="Blanca" last="Ramirez-Ruiz">Blanca Ramirez-Ruiz</name><name sortKey="Rene, Ramon" sort="Rene, Ramon" uniqKey="Rene R" first="Ramon" last="Rene">Ramon Rene</name><name sortKey="Sanchez Astaneda, Cristina" sort="Sanchez Astaneda, Cristina" uniqKey="Sanchez Astaneda C" first="Cristina" last="Sanchez-Castaneda">Cristina Sanchez-Castaneda</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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